Les effets anti-inflammatoires de la Mélatonine dans la sclérose en plaques

La sclérose en plaques est une maladie dans laquelle la myéline, la gaine d'isolation des cellules nerveuses du cerveau et de la moelle épinière, est endommagée. Ces lésions altèrent la capacité des différentes parties du système nerveux à communiquer entre elles, et engendrent de nombreux symptômes physiques et mentaux. La Mélatonine grâce aux effets anti-inflammatoires peut atténuer les conséquences.

Anti-inflammatory effects of melatonin ( mélatonine )in multiple sclerosis.

Bioessays. 2016 Aug 26;
Authors: Farez MF, Calandri IL, Correale J, Quintana FJ

Abstract
Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders. Over the years, it has become clear that melatonin ( mélatonine )may exacerbate some autoimmune conditions, whereas it alleviates others such as multiple sclerosis. Multiple sclerosis is an autoimmune disorder characterized by a dysregulated immune response directed against the central nervous system. Indeed, the balance between pathogenic CD4(+) T cells secreting IFN-γ (TH 1) or IL-17 (TH 17); and FoxP3(+) regulatory T cells and IL-10(+) type 1 regulatory T cells (Tr1 cells) is thought to play an important role in disease activity. Recent evidence suggests that melatonin ( mélatonine )ameliorates multiple sclerosis by controlling the balance between effector and regulatory cells, suggesting that melatonin-triggered signaling pathways are potential targets for therapeutic intervention. Here, we review the available data on the effects of melatonin ( mélatonine )on immune processes relevant for MS and discuss its therapeutic potential.

PMID: 27561251 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27561251?dopt=Abstract