Troubles de l'humeur sont plus fréquents où il y a des anomalies dans la sécrétion de la mélatonine.
Dans cette étude, nous avons analysé la corrélation entre des troubles affectifs et le volume de la glande pinéale. L'étude a révélé que les troubles affectifs, tels que les troubles de l'humeur (dépression et de manie) et les troubles anxieux, ont été associées à des altérations des rythmes circadiens due à des altérations de la sécrétion de mélatonine; notamment chez les patients ayant un volume réduit de la glande pinéale.
L'étude révèle en outre que les traitements qui ont pour objectif la régularisation des rythmes circadiens peuvent être utiles pour améliorer l'humeur chez les jeunes qui ont des troubles affectifs.Articolo in inglese
Pineal volume and evening melatonin ( mélatonine )in young people with affective disorders.
Brain Imaging Behav. 2016 Nov 3;
Authors: Carpenter JS, Abelmann AC, Hatton SN, Robillard R, Hermens DF, Bennett MR, Lagopoulos J, Hickie IB
Abstract
Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin ( mélatonine ) secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize these factors and explore associations with mood symptoms and functioning in a sample of young people with affective disorders. Pineal volume from magnetic resonance imaging and melatonin ( mélatonine )assay from evening dim-light saliva collection were evaluated in 50 individuals (15-30 years old; 72 % female) with bipolar, depressive, or anxiety disorders. Actigraphy monitoring was also conducted for approximately two weeks to derive sleep-wake measures. Pineal volume was associated with melatonin ( mélatonine )secretion across the evening, replicating previous findings in psychiatrically healthy individuals. Pineal volume was smaller in participants in which melatonin ( mélatonine )onset was not detected. Timing of melatonin ( mélatonine )secretion was related to sleep timing, but amount of melatonin ( mélatonine )and pineal volume were not related to any sleep-wake measures. A shorter phase angle between onset of melatonin ( mélatonine )secretion and sleep onset was associated with longer total sleep time. Lower melatonin ( mélatonine )levels were associated with poorer social and occupational functioning. Although pineal volume is not directly related to sleep disturbances or symptoms, melatonin ( mélatonine )may influence both sleep-wake cycles and functioning in the early stages of affective disorder. Causal links remain to be established, however, treatments that target circadian rhythms may be useful in improving functioning in young people with affective disorders.
PMID: 27812851 [PubMed - as supplied by publisher]
https://www.ncbi.nlm.nih.gov/
