Le sens de la mélatonine pour le traitement des troubles de l'humeur et la schizophrénie à travers l'activité des mitochondries

La mélatonine a un effet sur  le rythme circadien  et le sommeil, elle a aussi un effet dans le traitement  des troubles de l'humeur et la schizophrénie.  Nous prévoyons résumer des revues de recherches portant sur des questions de la mélatonine pour le traitement  des troubles de l'humeur et la schizophrénie  à travers  l'activité des mitochondries.

The importance of melatonin ( mélatonine )and mitochondria interaction in mood disorders and schizophrenia: A current assessment.

Curr Med Chem. 2016 Apr 27;

Authors: Uğuz AC, Demirci K, Palma JE

Abstract
Mitochondria play have a critical role in regulating cellular functions, such as redox signaling, calcium homeostasis, and apoptosis. Also, mitochondria are crucial for neurogenesis and neuronal functions. Melatonin is an indole analog hormone, which is generally produced by the pineal gland. It plays a vital role in circadian rhythm and act as a powerful antioxidant by scavenging free radicals, immunomodulators, and anticancer agents. Schizophrenia and mood disorders are the two major psychiatric disorders. Disturbances of sleep and circadian rhythms are well-known symptoms of schizophrenia and mood disorders (bipolar disorder, major depression). Since melatonin ( mélatonine )has a regulator effect on circadian rhythm and sleep quality, it has a close interaction with between schizophrenia and mood disorders. Herein, we aimed to summarize the effects of melatonin ( mélatonine )on mitochondrial activity in schizophrenia and mood disorders.

PMID: 27121187 [PubMed - as supplied by publisher]