Le syndrome métabolique. Études pour un possible traitement avec la mélatonine

Le syndrome métabolique désigné (SMet) désigne l'association d'une série de problèmes de santé ayant en commun un mauvais métabolisme corporel. il y a consensus pour parler de « syndrome métabolique » dans les cas où au moins 3 des problèmes suivants sont associés chez la même personne : taux d’insuline anormalement élevé, hypercholestérolémie, hypertension, excès de poids surtout s'il s'agit d'une obésité abdominale et hyperglycémie. La mélatonine diminue dans la sénescence notamment dans la résistance à l’insuline.

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies.

Neuroendocrinology. 2016 May 11;

Authors: Cardinali DP, Hardeland R

The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions. Melatonin levels decrease in the course of senescence and are more strongly reduced in diseases related to insulin resistance. This short review article analyzes the multiple protective actions of melatonin ( mélatonine )that are relevant to the attenuation of inflammatory responses and progression of inflammaging and how melatonin ( mélatonine )is effective to curtail MS in animal models of hyperadiposity. The clinical data supporting the possible therapeutical use of melatonin ( mélatonine )in human MS are also reviewed. Since attention has been focused on the development of potent melatonin ( mélatonine )analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, piromelatine) and in clinical trials these analogs were administered in doses considerably higher than those usually employed for melatonin, clinical trials on melatonin ( mélatonine )in the range of 50-100 mg/day are needed to further assess its therapeutic value in MS.

PMID: 27165273 [PubMed - as supplied by publisher]

Melatonine - Multilenguages section Key Melatonin